LSD addiction
Last Updated:
March 25th, 2025
LSD, celebrated for its historical mystique and countercultural symbolism, has intrigued scientists, artists, and thrill-seekers with its profound effects on perception and cognition; yet, the often overlooked reality of its potential harm and addiction underscores the importance of recognising these risks, fostering awareness of symptoms, and understanding effective recovery routes to encourage individuals grappling with LSD-related challenges to seek necessary help.
What is LSD?
Lysergic Acid Diethylamide, commonly known as LSD or “acid”, is a powerful, mind-altering substance known for its visual hallucinations and altered states of consciousness. Discovered in 1938 by Swiss chemist Albert Hofmann, LSD was initially used in psychiatric research and therapy but gained popularity in the 1960s counterculture movement for its profound effects on perception and consciousness. The drug is typically ingested orally via LSD-soaked blotter paper “tabs”, with its effects known as a “trip,” lasting up to 12 hours.
- Visual and sensory hallucinations or distortions or hallucinations
- Enhanced senses
- Differences in depth perception
- Synesthesia: “seeing” sounds and “hearing” colours
- Sweating
- Dry mouth
- Dizziness
- Tremors
- Increased energy
- Loss of appetite
- Insomnia
- Increased heart rate and blood pressure
- Euphoria
- Heightened, unstable emotions
- Dissociation
- Paranoia
- Delusions
- Impulsivity
- Anxiety
- Depression
How does LSD work?
Scientifically, LSD works by interacting with serotonin receptors in the brain, specifically the 5-HT2A receptor. Serotonin is a neurotransmitter that significantly influences various aspects of human behaviour, including mood, perception and cognition. When LSD binds to these receptors, it alters serotonin signalling and increases communication between different parts of the brain that don’t normally interact as much. It is this increased communication that is thought to trigger the unique alterations in consciousness and sensory perception experienced during an LSD trip.
While the psychedelic effects of LSD are well-documented, its potential therapeutic applications are still under exploration. Recent research has been investigating LSD’s potential in treating various mental health disorders, such as post-traumatic stress disorder (PTSD), depression and anxiety, especially in end-of-life care. However, these medical uses of LSD are not yet officially recognised, and more research is needed to understand its potential benefits and risks fully.
LSD fast facts
- LSD is derived from ergot, a fungus that grows on rye and other grains.
- The CIA experimented with LSD in the 1950s and 60s as part of the MK-Ultra project, investigating its potential for mind control.
- Flashbacks, or Hallucinogen Persisting Perception Disorder (HPPD), can occur long after the drug has been taken.